Hi Darkstar and Gopher. Thanks for the replies. I had actually tried deleting/renaming reaper.ini earlier. It cleared out all my settings, but the mouse wheel problem was still there. So it seems to go deeper than that. The only other mouse I have is the identical model to this, and it behaves the same way. But digging around in the advanced mouse driver settings in Control panel, I was able to semi-solve the problem: When I added reaper.exe to the "disable IntellPoint wheel support" list, the matrix and MIDI editor started scrolling correctly. But I lost *all* wheel scrolling in the track 'item' area of the main window (the track control panel on the left still scrolled correctly.) Strangely, there were already 5 applications in that list, none of which I actually own... the closest I come to any of them is Internet Explorer 5.0 (yes, that's 5.0! :)) Those must've been automatically set when I originally installed the mouse driver, so the problem I'm experiencing with Reaper would seem to be at least somewhat related to this known issue. There's an updated driver to the mouse, which I can imagine would fix the problem. But the driver verson I'm using lets me program it so that clicking the wheel sends a "Spacebar" command to specified programs, like Reaper and Sonar, which lets me start and stop the transport from the mouse... which is REALLY convenient and I'm addicted to it. But the newer driver for some reason omits the spacebar from the list of available keys that can be assigned to the different buttons. :( So I reverted. (Maybe a Reaper action would let me program that directly...? Have to look into that.) I guess I need to figure out which compromises I'm willing to make. But what else is new? hahaha Thanks for the kind welcome, Gopher. I'm finding Reaper too compelling to resist, learning curve and all, and I'm looking forward to using it "for real" and trying some from-scratch projects on it when I finally move over to my new computer. Thanks again for the suggestions!